Participation of the gut microbiome in the regulation of skeletal muscle metabolism

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The gut microbiota contributes to the regulation of skeletal muscle metabolism in various human functional states through a variety of formed metabolites that can be used as energy substrates or are signaling and regulatory molecules. The review presents the results of studies on the effects of bacterial short-chain fatty acids on signaling pathways regulating skeletal muscle metabolism and providing increased physical performance and improved human health.

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Sobre autores

I. Astratenkova

Saint Petersburg State University

Autor responsável pela correspondência
Email: astratenkova@mail.ru
Rússia, St. Petersburg

V. Rogozkin

Saint Petersburg Research Institute of Physical Culture

Email: astratenkova@mail.ru
Rússia, St. Petersburg

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2. Fig. 1. Signaling pathways involving short-chain fatty acids (SCFA) in the central nervous system (according to [13]).

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3. Fig. 2. Short-chain fatty acids regulate the expression of slow muscle fibers (according to [13]).

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4. Fig. 3. The effect of intestinal microbiome metabolites on endurance during aerobic exercise (according to [9]).

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5. Fig. 4. Molecular mechanism of action of dietary polysaccharides in reducing skeletal muscle fatigue (according to [29]).

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